Monday, August 4, 2014

Anti-inflammatory drugs could treat TNBC

Some triple-negative breast cancer tumors may benefit from JAK inhibitors, a class of anti-inflammatory drugs currently used to treat rheumatoid arthritis, according to research in Cell Reports.   
These tumors rely on an antiviral pathway related to inflammation, widely recognized for roles in cancer, rheumatoid arthritis, and other inflammatory diseases. Biologically, they have mutations of the proteins p53 and ARF.
"There are JAK inhibitors in use for rheumatoid arthritis and being tested against a number of other conditions,"  said senior author Jason D. Weber, PhD, of the Washington University School of Medicine in St. Louis, Missouri
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Janice sallee said...

Are there clinical trials for the anti inflamatory gene ?

Patricia Prijatel said...

I'd check with Washington University, where this research was done. They might know of studies in the pipeline. Also, has a list of clinical trials at And I have a link to news on clinical trials on this blog--look in the right hand column.